Our great lodging options include everything from full-service hotels to a charming new B&B …

Whether you’re in town of a weekend getaway, a youth sports tournament, or just passing through, Chillicothe has the perfect place for you to stay. You can find a spot in the heart of it all, or sneak away to enjoy your own quiet corner of northern Missouri. Come stay within reach of our greatest things!

Comfort Inn & Suites

250 West Business 36 Chillicothe, MO 64601(660) 646-9900

Your Morning Breakfast is full of hot and delicious options, making breakfast at the Comfort Inn & Suites the perfect way to start your day. Enjoy our free hot breakfast featuring eggs, meat, yogurt, fresh fruit, cereal and more, including your choice of hot waffle flavors! This hotel provides additional features for corporate travelers, including an on-site business center, public computer with Internet access, copy and fax service, and two banquet and meeting rooms. All well-appointed and spacious guest rooms are equipped with microwaves, refrigerators, coffee makers, 32-inch flat-screen televisions, cordless phones, desks, hair dryers, pillow-top mattresses, irons, ironing boards, safes and cable television with free HBO and HBO Family. Ask about our rooms that have sofa sleepers. Connecting rooms can be requested. Coin-operated laundry facilities are located on the premises and ample parking is provided.

Fairfield Inn & Suites by Marriott

220 West Business 36 Chillicothe, MO 64601(660) 646-3100

Travel with confidence at the only Fairfield Inn & Suites by Marriott north of I-70 in Chillicothe, Mo. Located right off of 36 Hwy, Chillicothe's newest hotel provides outstanding service with an easy and comfortable feel at an exceptional value. We are always ready to welcome you to our thoughtfully designed guest rooms and suites with plenty of room to work and relax. Free Wi-Fi throughout the hotel will keep you connected during your stay and our pool and fitness center will help you stay on track. Spread out in our vibrant lobby, with spaces to gather, relax and work. And jump-start each day with our free breakfast, now with more hot choices like scrambled eggs, sausage and oatmeal, plus favorites including fresh fruit and yogurt. You'll always find the courteous service you deserve, plus all the little things you expect from Fairfield Inn & Suites during your stay. Ask us about The Fairfield 100% Guarantee where we promise you'll be satisfied, or we'll make it right. That's our commitment to you.

Super 8

500 Business Hwy 36 East (Hwy 36 East and Mitchell Road) Chillicothe, MO 64601(660) 646-7888

Super 8 Hotel in Chillicothe offers guests the security and comfort of a modern facility with all indoor corridors. Our location is convenient to shopping, dining and attractions off of Route 36 between St. Joseph and Hannibal. Our hotel is ideal for your travels through Chillicothe. Count on free SuperStart continental breakfast every morning and stay connected to the Internet from the comfort of your room with free Wi-Fi. We offer free truck / RV parking and a microwave and refrigerator in all rooms. Our pet-friendly hotel features handicapped-accessible rooms, and kids 17 and under stay free with an adult. Our Super 8 is a Super Destination.

Starlite Motel

301 W Business 36 Chillicothe, MO 64601(660) 646-6329

Days Inn

1020 S Washington St Chillicothe, MO 64601(660) 646-0572